Testosterone propionate vs Cypionate | 100% Good Quality

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Testosterone propionate, sold under the brand name Testoviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. It has also been used to treat breast cancer in women. It is given by injection into muscle usually once every two to three days. Testosterone propionate vs cypionate.

Description

Testosterone propionate vs cypionate

Testosterone propionate vs cypionate, sold under the brand name Testoviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. It has also been used to treat breast cancer in women. It is given by injection into muscle usually once every two to three days.

Testosterone propionate is a slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.

Background Testosterone propionate vs cypionate

Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.2 Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.4

Structure

Weight
Average: 344.4877
Monoisotopic: 344.23514489
Chemical Formula
C22H32O3

Indication

Testosterone propionate is used in veterinary practice in heifers in order to stimulate maximal growth.4

Pharmacodynamics

The administration of testosterone propionate can induce production of proteins related to male sexual development.5 Clinical trials have shown a decrease in plasma LH after the administration of testosterone propionate.1 Testosterone propionate vs cypionate

Mechanism of action

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Testosterone propionate vs cypionate

Absorption

Testosterone propionate presents a slow absorption from the intramuscular site of administration. This slow absorption is due to the presence of the less polar ester group.5 The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.1 Testosterone propionate vs cypionate

Volume of distribution

The registered volume of distribution for testosterone propionate is in the range of 75-120 L/kg.1

Protein binding

Even 98% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound or bound to albumin and other proteins.3

Metabolism

As all testosterone esters, testosterone propionate is rapidly hydrolysed into free testosterone in plasma.1 Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).5 Testosterone propionate vs cypionate

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Route of elimination

About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites. From the rest of the dose, approximately 6% of a dose is excreted in the feces, mostly in the unconjugated form.5 Testosterone propionate vs cypionate

Half-life

Testosterone propionate possesses a relatively short half-life compared with other testosterone esters at approximately 4.5 days.

Clearance

Testosterone propionate has a reduced clearance rate compared to testosterone.5 The reported clearance rate is of approximately 2000 ml/min.1

Toxicity

Reports have showed a potential stimulation of cancerous tissue growth. The potential testosterone propionate accumulation in the body produces a high risk of edema secondaryh to water and sodium retention.5 Testosterone propionate vs cypionate

 

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