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Tamoxifen(Nolvadex) is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman’s chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Where to buy nolvadex | Nolvadex bodybuilding.

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Description

What is Nolvadex and how is it used? | Nolvadex bodybuilding

Nolvadex is a prescription medicine used to treat the symptoms of Breast Cancer. Nolvadex may be used alone or with other medications.

Nolvadex belongs to a class of drugs called Antineoplastics, Estrogen Receptor Antagonists.

It is not known if Nolvadex is safe and effective in children.

What are the possible side effects of Nolvadex? | Nolvadex bodybuilding

Nolvadex may cause serious side effects including:

  • vision changes,
  • eye pain,
  • easy bruising or bleeding,
  • mood changes,
  • swelling of the ankles or feet, and
  • unusual tiredness

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Nolvadex include:

  • hot flashes,
  • flushing,
  • changes in menstrual periods,
  • nausea,
  • leg cramps,
  • abdominal cramps,
  • bone pain,
  • muscle pain,
  • cough,
  • swelling,
  • fatigue,
  • hair thinning,
  • headache,
  • depression, and
  • loss of sexual ability/interest (in men)

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Nolvadex. For more information, ask your doctor or pharmacist. Nolvadex bodybuilding.

WARNING

For Women with Ductal Carcinoma in Situ (DCIS) and Women at High Risk for Breast Cancer: Serious and life-threatening events associated with NOLVADEX (tamoxifen citrate) in the risk reduction setting (women at high risk for cancer and women with DCIS) include uterine malignancies, stroke and pulmonary embolism. Incidence rates for these events were estimated from the NSABP P-1 trial (see CLINICAL PHARMACOLOGY-Clinical Studies – Reduction in Breast Cancer Incidence In High Risk Women). Nolvadex bodybuilding.

Uterine malignancies consist of both endometrial adenocarcinoma (incidence rate per 1,000 women-years of 2.20 for NOLVADEX (tamoxifen citrate) vs 0.71 for placebo) and uterine sarcoma (incidence rate per 1,000 women-years of 0.17 for NOLVADEX (tamoxifen citrate) vs 0.4 for placebo)*. For stroke, the incidence rate per 1,000 women-years was 1.43 for NOLVADEX (tamoxifen citrate) vs 1.00 for placebo**. For pulmonary embolism, the incidence rate per 1,000 women-years was 0.75 for NOLVADEX (tamoxifen citrate) versus 0.25 for placebo**. Where to buy nolvadex | Nolvadex bodybuilding. Where to buy nolvadex.

Some of the strokes, pulmonary emboli, and uterine malignancies were fatal.

Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering NOLVADEX (tamoxifen citrate) to reduce their risk of developing breast cancer. Nolvadex bodybuilding

The benefits of NOLVADEX (tamoxifen citrate) outweigh its risks in women already diagnosed with breast cancer.

REFERENCES

*Updated long-term follow-up data (median length of follow-up is 6.9 years) from NSABP P-1 study. See WARNINGS: Effects on the Uterus-Endometrial Cancer and Uterine Sarcoma. Nolvadex bodybuilding.

DESCRIPTION

NOLVADEX® (tamoxifen citrate) Tablets, a nonsteroidal antiestrogen, are for oral administration. NOLVADEX (tamoxifen citrate) Tablets are available as:

10 mg Tablets

Each tablet contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

20 mg Tablets

Each tablet contains 30.4 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.

Inactive Ingredients: carboxymethylcellulose calcium, magnesium stearate, mannitol and starch.

Chemically, NOLVADEX (tamoxifen citrate) is the trans-isomer of a triphenylethylene derivative. The chemical name is (Z)2-[4-(1,2-diphenyl-1-butenyl) phenoxy]-N, N-dimethylethanamine 2 hydroxy-1,2,3- propanetricarboxylate (1:1). The structural and empirical formulas are: Nolvadex bodybuilding

 

 

NOLVADEX (Tamoxifen Citrate) Structural Formula Illustration

 

Tamoxifen citrate has a molecular weight of 563.62, the pKa’ is 8.85, the equilibrium solubility in water at 37°C is 0.5 mg/mL and in 0.02 N HCl at 37°C, it is 0.2 mg/mL.

INDICATIONS

Metastatic Breast Cancer

NOLVADEX (tamoxifen citrate) is effective in the treatment of metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, NOLVADEX (tamoxifen citrate) is an alternative to oophorectomy or ovarian irradiation. Available evidence indicates that patients whose tumors are estrogen receptor positive are more likely to benefit from NOLVADEX (tamoxifen citrate) therapy. Where to buy nolvadex | Nolvadex bodybuilding

Adjuvant Treatment of Breast Cancer

NOLVADEX (tamoxifen citrate) is indicated for the treatment of node-positive breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. In some NOLVADEX (tamoxifen citrate) adjuvant studies, most of the benefit to date has been in the subgroup with four or more positive axillary nodes. Where to buy nolvadex | Nolvadex bodybuilding

NOLVADEX (tamoxifen citrate) is indicated for the treatment of axillary node-negative breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. Where to buy nolvadex | Nolvadex bodybuilding

The estrogen and progesterone receptor values may help to predict whether adjuvant NOLVADEX (tamoxifen citrate) therapy is likely to be beneficial.

NOLVADEX (tamoxifen citrate) reduces the occurrence of contralateral breast cancer in patients receiving adjuvant NOLVADEX (tamoxifen citrate) therapy for breast cancer.

Ductal Carcinoma in Situ (DCIS)

In women with DCIS, following breast surgery and radiation, NOLVADEX (tamoxifen citrate) is indicated to reduce the risk of invasive breast cancer (see BOXED WARNING at the beginning of the label). The decision regarding therapy with NOLVADEX (tamoxifen citrate) for the reduction in breast cancer incidence should be based upon an individual assessment of the benefits and risks of NOLVADEX (tamoxifen citrate) therapy. Where to buy nolvadex | Nolvadex bodybuilding

Current data from clinical trials support five years of adjuvant NOLVADEX (tamoxifen citrate) therapy for patients with breast cancer.

Reduction in Breast Cancer Incidence in High Risk Women

NOLVADEX (tamoxifen citrate) is indicated to reduce the incidence of breast cancer in women at high risk for breast cancer. This effect was shown in a study of 5 years planned duration with a median follow-up of 4.2 years. Twenty-five percent of the participants received drug for 5 years. The longer-term effects are not known. In this study, there was no impact of tamoxifen on overall or breast cancer-related mortality (see BOXED WARNING at the beginning of the label). Where to buy nolvadex | Nolvadex bodybuilding

NOLVADEX (tamoxifen citrate) is indicated only for high-risk women. “High risk” is defined as women at least 35 years of age with a 5-year predicted risk of breast cancer ≥ 1.67%, as calculated by the Gail Model.

 

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