Lonafarnib Zokinvy price | Zokinvy cost | 100% Good Quality
Zokinvy (lonafarnib) a prescription medicine used in people with certain rare genetic conditions that cause premature and rapid aging. Lonafarnib is for use in adults and children at least 12 months old whose bodies have reached a certain size (a body surface area of 0.39 square meters). Zokinvy price | Zokinvy cost
Uses | Lonafarnib Zokinvy price | Zokinvy cost
Lonafarnib Zokinvy price | Zokinvy cost . This medication is used to lower the risk of death in people with a certain rare condition (Hutchinson-Gilford Progeria Syndrome – HGPS). It is also used to treat people with certain other rare conditions (Progeroid Laminopathies). Lonafarnib works by decreasing the amount of a harmful substance (progerin) caused by these conditions.
How to use Zokinvy 75 Mg Capsule Progeria Syndrome Treatment Agents
Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using lonafarnib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Lonafarnib Zokinvy price | Zokinvy cost
Take this medication by mouth as directed by your doctor, usually twice a day: once with the morning meal and once with the evening meal. Swallow the capsules whole with water. Do not crush or chew. Lonafarnib Zokinvy price | Zokinvy cost
If you have trouble swallowing the capsule, it may be opened and the contents mixed as directed in orange juice, applesauce, or certain liquids used to make a suspension. Swallow the mixture within 10 minutes of mixing it. Do not save the mixture for future use. Lonafarnib Zokinvy price | Zokinvy cost
Avoid eating grapefruit or Seville oranges or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Do not mix the contents of the capsule in juice containing grapefruit or Seville oranges. Grapefruit and Seville oranges can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. Lonafarnib Zokinvy price | Zokinvy cost
The dosage is based on your medical condition, body size, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Lonafarnib Zokinvy price | Zokinvy cost
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Do not increase your dose or use this drug more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.
Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Lonafarnib Zokinvy price | Zokinvy cost
A total of 84 subjects were treated with at least one dose of ZOKINVY with or without additional therapy, of which 8 were treated at a dosage of at least 115 mg/m2 twice daily for greater than or equal to 10 years. Lonafarnib Zokinvy price | Zokinvy cost
The safety profile of ZOKINVY is based on 128 patient-years of treatment exposure (62 patients with HGPS and 1 patient with processing-deficient Progeroid Laminopathy with LMNA heterozygous mutation) and pooled results from two Phase 2 open-label, single-arm trials (n=63: 28 patients from Study 1 and 35 treatment naïve patients from Study 2). In Study 1, ZOKINVY treatment was initiated at 115 mg/m2 twice daily and increased to 150 mg/m2 twice daily after approximately 4 months for a total treatment duration of 24 to 30 months. Treatment naïve patients in Study 2 received ZOKINVY 150 mg/m2 twice daily for up to 36 months. In both studies, ZOKINVY was administered orally via capsules or the capsule contents were mixed with Ora Blend SF or Ora-Plus and administered orally as a suspension. Lonafarnib Zokinvy price | Zokinvy cost
In these two studies, a total of 63 patients received ZOKINVY for a median duration of 2.2 years, with approximately 1.9 years at the recommended dose of 150 mg/m2 twice daily. The population was 2 to 17 years old, with a similar proportion of males (33 [52%] patients) and females (30 [48%] patients). Most patients had classic HGPS (60 [95%] patients) compared to non-classic HGPS (2 [3%] patients) and 1 (2%) patient had Progeroid Laminopathy with LMNA heterozygous mutation. Lonafarnib Zokinvy price | Zokinvy cost
Table 3 summarizes adverse reactions reported in the clinical trials. The most common adverse reactions (≥25%) in the clinical trials were vomiting, diarrhea, infection, nausea, decreased appetite, fatigue, upper respiratory tract infection, abdominal pain, musculoskeletal pain, electrolyte abnormalities, decreased weight, headache, myelosuppression, increased aspartate aminotransferase, decreased blood bicarbonate, cough, hypertension, and increased alanine aminotransferase. Lonafarnib Zokinvy price | Zokinvy cost
What to avoid
Grapefruit and Seville oranges may interact with lonafarnib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.
Zokinvy side effects
Get emergency medical help if you have signs of an allergic reaction to Zokinvy: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- new or worsening vision problems (such as decreased night vision);
- severe ongoing nausea, vomiting, diarrhea;
- loss of appetite that causes weight loss;
- high blood pressure – severe headache, blurred vision, shortness of breath, nosebleeds, pounding in your neck or ears;
- kidney problems – little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
- high potassium level – nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
- low potassium level – leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
- low sodium level – headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- low calcium level – muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or
- signs of infection – fever, chills, cough, rash, swelling, diarrhea, pain or burning when you urinate.
Common Zokinvy side effects may include:
- an electrolyte imbalance (such as low levels of potassium, sodium, or calcium in your blood);
- increased blood pressure;
- stomach pain, nausea, vomiting, diarrhea;
- decreased appetite, weight loss;
- feeling tired;
- muscle or joint pain;
- cold symptoms such as stuffy nose, sneezing, sore throat, cough; or
- abnormal lab tests;