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Folotyn is a medicine that contains the active substance pralatrexate. It was to be available as a solution for infusion (drip into a vein). Folotyn Price.
What is Folotyn? | Folotyn price
Folotyn/Folotyn price (pralatrexate) is a cancer medication.
Folotyn is used to treat T-cell lymphoma that has spread throughout the body.
Folotyn is given for relapsed T-cell lymphoma, or after other medications have been tried without successful treatment.
What is Folotyn and how is it used? | Folotyn price
Folotyn (pralatrexate injection) is an antineoplastic (anti-cancer) drug used to treat T-cell lymphoma that has spread throughout the body. Folotyn is given for relapsed T-cell lymphoma, or after other medications have been tried without successful treatment. Folotyn Price.
What are side effects of Folotyn? | Folotyn price
Common side effects of Folotyn include:
- redness or sores of the mouth/lips/throat
- loss of appetite
- tired feeling
- mild rash or itching
- low platelet count.
Serious skin reactions can occur. Tell your doctor if you develop rash, peeling, sores or blisters on the skin while using Folotyn. Tell your doctor if you have unlikely but serious side effects of Folotyn including:
- signs of infection (such as fever, cough, sore throat, chills),
- easy bleeding or bruising,
- feeling weak,
- looking pale, or
- shortness of breath.
FOLOTYN (pralatrexate injection) contains pralatrexate, which is an antineoplastic folate analog. Pralatrexate has the chemical name (2S)-2-[[4-[(1RS)-1-[(2, 4-diaminopteridin-6-yl)methyl]but-3- ynyl]benzoyl]amino]pentanedioic acid. The structural formula is as follows:
Pralatrexate is a 1:1 racemic mixture of S- and R- diastereomers at the C10 position (indicated with *).
The molecular formula is C23H23N7O5 and the molecular weight is 477.48 g/mol.
Pralatrexate is an off-white to yellow solid. It is soluble in aqueous solutions at pH 6.5 or higher. Pralatrexate is practically insoluble in chloroform and ethanol. The pKa values are 3.25, 4.76, and 6.17.
FOLOTYN is supplied as a preservative-free, sterile, isotonic, non-pyrogenic clear yellow aqueous parenteral solution contained in a single-dose clear glass vial (Type I) for intravenous administration. Each 1 mL of solution contains 20 mg of pralatrexate, sufficient sodium chloride to achieve an isotonic (280-300 mOsm) solution, and sufficient sodium hydroxide, and hydrochloric acid if needed, to adjust and maintain the pH at 7.5-8.5. FOLOTYN is supplied as either 20 mg (1 mL) or 40 mg (2 mL) singledose vials at a concentration of 20 mg/mL. Folotyn Price.
Important things to remember about the side effects of Folotyn®:
- Most people do not experience all of the side effects listed.
- Side effects are often predictable in terms of their onset and duration.
- Side effects are almost always reversible and will go away after treatment is complete.
- There are many options to help minimize or prevent side effects.
- There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients taking Folotyn®:
These side effects are less common side effects (occurring in about 10-29%) of patients receiving Folotyn®:
- Nose Bleeds
- Decreased white blood cell count
- Shortness of breath
- Low Potassium
- Lack of appetite
- Sore throat
- Elevated Liver Enzymes
- Abdominal Pain
- Limb pain
- Back Pain
- Night sweats
- Increased Heart Rate
- Upper respiratory tract infection
Get emergency medical help if you have signs of an allergic reaction to Folotyn (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Folotyn Price.
Call your doctor at once if you have:
- liver problems – loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- signs of tumor cell breakdown – tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth;
- low white blood cell counts – fever, skin sores, sore throat, cough, trouble breathing;
- low red blood cells (anemia) – pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;
- low potassium level – leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
- dehydration symptoms – feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.
Common Folotyn side effects may include:
- sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;
- easy bruising, unusual bleeding, purple or red spots under your skin;
- nausea; or
- feeling tired.